Targeting Neurohumoral Signaling to Treat Pulmonary Hypertension: The Right Ventricle Coming Into Focus Running title: Maron; Abnormal adrenergic signaling in pulmonary hypertension
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منابع مشابه
Targeting neurohumoral signaling to treat pulmonary hypertension: the right ventricle coming into focus.
Adverse remodeling of the right ventricle (RV) that affects RV systolic or diastolic function directly or indirectly by modulating changes to cavitary geometry is a principal determinant of poor outcome across the global spectrum of cardiopulmonary diseases.1,2 Indeed, even subclinical increases in RV mass are associated with substantially elevated risk for future heart failure and decreased li...
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The function of the right ventricle (RV) determines the prognosis of patients with pulmonary hypertension. While much progress has been made in the treatment of pulmonary hypertension, therapies for the RV are less well established. In this review of treatment strategies for the RV, first we focus on ways to reduce wall stress since this is the main determinant of changes to the ventricle. Seco...
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Background and Objective: Pulmonary hypertension is an increase in blood pressure of the pulmonary artery which leads to right ventricular dysfunction. Therefore, the present study aimed to compare echocardiographic parameters in the study of right ventricular failure in patients with pulmonary hypertension. Materials and Methods: In the present descriptive cross-sectional study, data were col...
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Pulmonary hypertension (PH) is characterized by pathological changes to cell signaling pathways within the alveolar-pulmonary arteriole-right ventricular axis that results in increases in pulmonary vascular resistance and, ultimately, the development of right ventricular (RV) dysfunction. Cornerstone histopathological features of the PH vasculopathy include intimal thickening, concentric hypert...
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